Bupropion's mechanism includes inhibition of reuptake of which neurotransmitters?

• A. Dopamine + norepinephrine reuptake inhibitor
• B. Serotonin reuptake inhibitors
• C. GABA reuptake inhibitors
• D. Acetylcholine reuptake inhibitors

Answer: (A)

Bupropion works mainly by blocking the reuptake of dopamine and norepinephrine, making it an norepinephrine-dopamine reuptake inhibitor. By increasing these two neurotransmitters in the synapse, it helps elevate mood and energy and can reduce nicotine withdrawal symptoms. It does not significantly affect serotonin reuptake, so serotonin reuptake inhibitors are not its mechanism. It also does not act as a GABA or acetylcholine reuptake inhibitor. An additional, related effect is antagonism at nicotinic receptors, which contributes to its smoking cessation benefits, but the primary reuptake action to focus on is dopamine and norepinephrine.