In patients with glaucoma, which medications are listed?

• A. Liraglutide, orlistat, lorcaserin
• B. Metformin
• C. Phentermine/topiramate
• D. Lorcaserin

Answer: (A)

When evaluating medications for patients with glaucoma, it’s important to consider how systemic drugs can affect the eye, particularly intraocular pressure and the risk of angle-closure events. Liraglutide, orlistat, and lorcaserin are grouped together here because they do not carry known ocular risks that would complicate glaucoma management. They don’t have established associations with increasing intraocular pressure or precipitating glaucoma-related complications, so they’re listed as options that fit the glaucoma context.

In contrast, a regimen that includes a drug like topiramate (as in a phentermine/topiramate combination) is avoided in glaucoma because topiramate can trigger acute secondary angle-closure glaucoma by causing ciliochoroidal effusion and forward displacement of the lens-iris diaphragm. That known risk makes that option less appropriate for patients with glaucoma. The other choices don’t align with the listed trio in the same way, so they’re not the best fit for this prompt.