Which hormone is secreted in response to glucose and promotes insulin release from the pancreas and satiety?

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Multiple Choice

Which hormone is secreted in response to glucose and promotes insulin release from the pancreas and satiety?

Glucose in the gut prompts the release of incretin hormones, with GLP-1 playing a central role. GLP-1 is produced by intestinal L cells in response to nutrients and boosts insulin secretion from pancreatic beta cells in a glucose-dependent manner, helping to curb post-meal blood sugar. It also acts on the brain to promote satiety, reducing further food intake. Ghrelin drives hunger, not insulin release; leptin signals longer-term energy stores and influences appetite over time; and PYY helps reduce appetite after a meal but does not directly enhance glucose-induced insulin release. So GLP-1 best explains both the insulinotropic effect and the increase in satiety.

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