Which medications are listed for patients with addiction/alcohol abuse hx, and cautions are included?

• A. Orlistat, liraglutide, lorcaserin - may cause euphoria; naltrexone/bupropion - lowers seizure threshold and contraindicated during alcohol withdrawal
• B. Phentermine/topiramate
• C. Metformin
• D. Liraglutide only

Answer: (A)

When assessing medication choices for patients with a history of addiction or alcohol misuse, it’s crucial to weigh potential abuse risk and specific cautions that can be triggered by withdrawal or seizures. The best option includes several weight-management medicines and clear warnings that are particularly relevant in this context: some of these agents have a potential for euphoria, which matters for someone with a history of addiction, and there is a significant seizure risk with the naltrexone/bupropion combination, especially during alcohol withdrawal, where it is contraindicated. The other choices either present fewer relevant medications or omit the important cautions, so they don’t address safety in patients with addiction history as fully.