Which of the following is a sulfonylurea associated with weight gain?

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Multiple Choice

Which of the following is a sulfonylurea associated with weight gain?

Explanation:
Sulfonylureas increase insulin secretion from pancreatic beta cells. Higher circulating insulin promotes glucose uptake and storage as fat, and reduces fat breakdown, which leads to weight gain. Glipizide is a sulfonylurea, so it shares this effect and is associated with weight gain. In contrast, metformin tends to be weight-neutral or modestly weight-reducing, exenatide often promotes weight loss through appetite suppression and slower gastric emptying, and while pioglitazone can also cause weight gain, its primary action is improving insulin sensitivity via a different mechanism.

Sulfonylureas increase insulin secretion from pancreatic beta cells. Higher circulating insulin promotes glucose uptake and storage as fat, and reduces fat breakdown, which leads to weight gain. Glipizide is a sulfonylurea, so it shares this effect and is associated with weight gain. In contrast, metformin tends to be weight-neutral or modestly weight-reducing, exenatide often promotes weight loss through appetite suppression and slower gastric emptying, and while pioglitazone can also cause weight gain, its primary action is improving insulin sensitivity via a different mechanism.

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