Which of the following is NOT listed as a drug that induces weight gain?

• A. Ortho Tri-Cyclen
• B. Metformin
• C. Risperidone
• D. Glipizide

Answer: (B)

The key idea here is that many medications have predictable effects on body weight, and metformin is a classic example that does not cause weight gain. Metformin typically leads to weight loss or, at worst, weight stability because it improves insulin sensitivity and lowers hepatic glucose production, which helps reduce risks of fat storage. This contrasts with the other drugs listed, which are well-known to be associated with weight gain: one option can cause fluid retention and increased appetite; another antipsychotic often increases appetite and metabolic changes; and a sulfonylurea increases insulin levels, promoting weight gain. So the drug that does not induce weight gain is metformin.