Which option is listed for post-operative weight regain management?

• A. Lifestyle intervention + Liraglutide OR phentermine/topiramate
• B. Metformin only
• C. Orlistat only
• D. Lorcaserin only

Answer: (A)

Post-operative weight regain management focuses on continuing lifestyle changes while adding medical therapy when needed. After bariatric surgery, diet, activity, and behavior modification remain essential, and pharmacologic support can help boost long-term weight loss or prevent regain. Two medications that have shown benefit in this context are liraglutide, a GLP-1 receptor agonist, and the phentermine/topiramate combination. Using lifestyle intervention together with one of these options addresses both behavior and physiology to support sustained weight loss, which is why this option is the best choice.

Metformin alone isn’t a primary weight-management medication, and orlistat alone may have limited effectiveness post-surgery and can cause gastrointestinal or vitamin malabsorption issues. Lorcaserin has been withdrawn from the market due to safety concerns, so it isn’t a current option.