Lorcaserin acts on which receptor type to promote weight loss?

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Multiple Choice

Lorcaserin acts on which receptor type to promote weight loss?

Lorcaserin promotes weight loss by acting as a selective agonist at the serotonin 2C receptor (5-HT2C) in the hypothalamus. Activation of 5-HT2C increases the activity of POMC neurons, leading to the release of anorexigenic peptides that stimulate melanocortin-4 receptors and produce satiety, which lowers food intake. This receptor-specific action explains its weight-reducing effect and helps avoid the cardiovascular risks linked to other serotonin receptor subtypes. The other receptors listed (dopamine D2, GABA-B, NMDA) are not the targets of lorcaserin and do not account for its appetite-suppressing action.

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