Which combination is contraindicated during alcohol withdrawal due to seizure risk?

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Multiple Choice

Which combination is contraindicated during alcohol withdrawal due to seizure risk?

Alcohol withdrawal heightens the risk of seizures, so medications that can lower the seizure threshold are avoided in this setting. Bupropion is known to lower the seizure threshold, and when it’s combined with naltrexone, that overall regimen becomes contraindicated during alcohol withdrawal because of the added seizure risk. The other options don’t carry this specific risk: topiramate has anticonvulsant properties, and lorcaserin and liraglutide have no notable effect on seizure threshold in this context, so they’re not contraindicated for seizure risk during withdrawal.

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